2010;105(6):1338-1345. Wadzinski, J., Franks, R., Roane, D., and Bayard, M. Valproate-associated hyperammonemic encephalopathy. Oncologist 2010;15:200-11. Eur J Heart Fail. Thomas, S., Fischer, F. P., Mettang, T., Pauli-Magnus, C., Weber, J., and Kuhlmann, U. 2015;53(11):980-6. Cell Biochem.Funct. View abstract. Patients with medium-chain acyl-coenzyme a dehydrogenase deficiency have impaired oxidation of fat during exercise but no effect of L-carnitine supplementation. JPEN J Parenter.Enteral Nutr. Cavallini G, Caracciolo S, Vitali G, et al. Helms, R. A., Whitington, P. F., Mauer, E. C., Catarau, E. M., Christensen, M. L., and Borum, P. R. Enhanced lipid utilization in infants receiving oral L-carnitine during long-term parenteral nutrition. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Acta Cardiol. Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Saudi.J Kidney Dis Transpl. Footitt, E. J., Stafford, J., Dixon, M., Burch, M., Jakobs, C., Salomons, G. S., and Cleary, M. A. J Peripher Nerv Syst 1997;2:250-2. Dig Dis 2021. Wyss, V., Ganzit, G. P., and Rienzi, A. Crill, C. M., Storm, M. C., Christensen, M. L., Hankins, C. T., Bruce, Jenkins M., and Helms, R. A. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Drugs Exp Clin Res 1992;18(4):147-153. Acta Neurol.Taiwan. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. Clin Ther 2003;25(5):1429-1439. Yano J, Kaida Y, Maeda T, et al. Last updated on Aug 31, 2022. View abstract. Carnitor (levocarnitine)." Heuberger W, Berardi S, Jacky E, et al. 2013;38(1):31-41. J Assoc Physicians India 2000;48(11):1050-1052. View abstract. Goral S. Levocarnitine and muscle metabolism in patients with end-stage renal disease. FDA. (Rome) 2010;11(9):703-705. View abstract. This is not a complete list of side effects and others may occur. Kraft, M., Kraft, K., Gartner, S., Mayerle, J., Simon, P., Weber, E., Schutte, K., Stieler, J., Koula-Jenik, H., Holzhauer, P., Grober, U., Engel, G., Muller, C., Feng, Y. S., Aghdassi, A., Nitsche, C., Malfertheiner, P., Patrzyk, M., Kohlmann, T., and Lerch, M. M. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial. Endocr J. Davini P, Bigalli A, Lamanna F, Boem A. Pacheco, A., Torres, R., Sanhueza, M. E., Elgueta, L., Segovia, E., and Cano, M. [Study of aerobic capacity in chronic hemodialized patients: effect of L-carnitine supplementation]. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. A cross-over study vs placebo. View abstract. Clin Eur 1983;22:405-415. L-Carnitine is not expected to harm an unborn baby. Brand names: Carnitor, L-Carnitine Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. 2010;20(11):693-700. Some side effects may not be reported. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. 2010;42(10):1809-1818. A., Ebenezer, G. J., Hauer, P., Millar, L., Gould, M., Tran, P., Shikuma, C., Souza, S., and McArthur, J. C. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. View abstract. Neurobiol Aging 1995;16:1-4. L-carnitines main role in your body involves mitochondrial function and energy production (3, 15, 16). [Use of L-carnitine before percutaneous epididymal sperm aspiration-intracytoplasmic sperm injection for obstructive azoospermia]. Winter SC, Szabo-Aczel S, Curry CJR, et al. 11. Biomed Rep 2020;13(6):65. View abstract. JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. Amino.Acids 2008;35(2):419-423. Calabrese, V., Colombrita, C., Sultana, R., Scapagnini, G., Calvani, M., Butterfield, D. A., and Stella, A. M. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function. View abstract. J Nutr.Biochem. Low levels of L-carnitine have been found to be associated with diabetic complications. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. View abstract. Levocarnitine. Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Ital J Neurol Sci 1981;2(3):255-262. View abstract. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. Methods Mol.Biol. Arzneimittelforschung 1992;42:1101-4. nausea or vomiting Less common Abdominal discomfort body odor depression dizziness impaired vision loss of appetite or weight swelling in hands, lower legs, and feet tingling sensation weakness For Healthcare Professionals Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. Eur.Urol. J Am Coll Nutr 1999;18:77-82. Eur J Appl Physiol Occup.Physiol 1990;60(1):1-6. View abstract. Br J Dermatol 1987;117:203-6. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Pettegrew, J. W., Levine, J., Gershon, S., Stanley, J. View abstract. 2010;7:16. View abstract. Skip the missed dose if it is almost time for your next scheduled dose. J Infect Dis 1997;176:1517-23. View abstract. View abstract. Cardiovasc Drugs Ther 1995;9:749-53. View abstract. View abstract. View abstract. View abstract. View abstract. J Clin Oncol. Karanth, J. and Jeevaratnam, K. Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity. A., Flory, J., Rowan, C. G., and Brunelli, S. M. Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis. 2006;176(4 Pt 1):1307-1312. 2007;31(11):1414-1419. 5A5 Steak Lounge. View abstract. A., and Morrow, G. R. Pharmacologic treatment of cancer-related fatigue. Yeh, Y. Y., Cooke, R. J., and Zee, P. Impairment of lipid emulsion metabolism associated with carnitine insufficiency in premature infants. Plioplys AV, Kasnicka I. L-carnitine as a treatment for Rett syndrome. China Tropical Med 2007;7(5):753-754. 2008;14(2):149-151. Cardiovasc.Drugs Ther 2007;21(6):445-448. Efficacy of L-carnitine and propranolol in the management of acute theophylline toxicity. A., and Barrington, K. J. Zhang, W., Miao, J., Zhang, G., Liu, R., Zhang, D., Wan, Q., Yu, Y., Zhao, G., and Li, Z. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Caponnetto S, Canale C, Masperone MA, et al. Csiky, B., Nyul, Z., Toth, G., Wittmann, I., Melegh, B., Rauh, M., Rascher, W., and Sulyok, E. L-carnitine supplementation and adipokines in patients with end-stage renal disease on regular hemodialysis. A., Cotman, C. W., and Sullivan, P. G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Caruso U, Leone L Cravotto E Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. 1. Am J Dis Child 1987;141:660-5. Boehm G, Stahl B. Oligosaccharides from milk. 2011;60(1):85. Arch Intern Med 1999;159:1143-4. DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Xue, Y. View abstract. 2010;15(2):200-211. Eur J Clin Pharmacol 1998;54:503-8. Naito J, Ohashi H, Ohno M, et al. Kidney Int 1990;38(5):904-911. Karalis DT, Karalis T, Karalis S, Kleisiari AS. 2010;28(2):127-132. Xie, J., Zeng, Q., and Wang, L. The protective effect of L-carnitine on ischemia-reperfusion heart. Stuessi, C., Hofer, P., Meier, C., and Boutellier, U. L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. View abstract. Metabolism Boosters: Weight Loss Fact or Fiction? A double-blinded, crossover study. Symptoms include relentless fatigue during the day, not feeling rested after sleep, insomnia, reduced sex drive, a "wired and tired" feeling, a reduced ability to concentrate and feel relaxed, and weight gain, especially in the stomach. Clin Exp.Hypertens. View abstract. Rizos I. Lisinopril (lisinipril) should be stopped if there are symptoms or signs of an allergic reaction including feelings of swelling of the face, lips, tongue or throat. J Med.Food 2006;9(4):468-473. Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial. Am.J Clin Nutr. Rajasekar, P. and Anuradha, C. V. L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management. 2019;14(6):504-514. Int J Clin Pharmacol Res 1990;10:75-9. Merchant, R., Jain, A., Udani, A., Puri, V., and Kotian, M. L-carnitine in beta thalassemia. 2011;(6):CD003917. J Cardiol 1991;21(2):493-504. Novak M, Monkus EF, Buch M, and et al. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology 2003;47:94-7. Karl M, Rubenstein M, Rudnick C, Brejda J. Clin Ter. Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a . J Inherit.Metab Dis 2009;32(4):488-497. View abstract. Side Effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In one review of L-carnitines safety, doses of approximately 2 grams per day appeared to be safe for long-term use. View abstract. 2013;32(1):41-9. Sweets. Circ.J 2008;72(6):926-931. View abstract. Nutr.Res. View abstract. Medically reviewed by Drugs.com on Jun 6, 2022. View abstract. Sole MJ, Jeejeebhoy KN. 2009;10(2):103-110. View abstract. L-carnitine is best known as a fat burner, but the overall research is mixed. View abstract. Dalakas MC, Leon-Monzon ME, Bernardini I, et al. It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina). Guan, Y., Zheng, X. M., Yang, Z. W., and Li, S. W. [Protective effects of L-carnitine upon testicular ischemia-reperfusion damage in rats]. L-carnitine may increase the risk of seizures in those with epilepsy. View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. View abstract. View abstract. Multicenter clinical placebo-controlled study with acetyl-L-carnitine in the treatment of mildly demented elderly patients. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. View abstract. J Inherit.Metab Dis 2006;29(2-3):288-298. 2000;54(6):470-477. Bella R, Biondi R, Raffaele R, Pennisi G. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. "Product Information. Oncologist. BMC Public Health. Cacciatore L, Cerio R, Ciarimboli M, et al. View abstract. Epilepsia 1998;39:1216-25. Pediatr.Neurol. Ahmad S, Robertson HT, Golper TA, et al. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. Cai, T., Wagenlehner, F. M., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., Tiscione, D., Malossini, G., and Bartoletti, R. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. View abstract. View abstract. Sohn HJ, Choi GB Yoon KI. View abstract. View abstract. View abstract. View abstract. Pittler, M. H. and Ernst, E. Complementary therapies for neuropathic and neuralgic pain: systematic review. Romano, M., Vacante, M., Cristaldi, E., Colonna, V., Gargante, M. P., Cammalleri, L., and Malaguarnera, M. L-carnitine treatment reduces steatosis in patients with chronic hepatitis C treated with alpha-interferon and ribavirin. 2012;4:CD006282. [Acetylcarnitine and spermatozoa: relationship with epididymal maturation and motility in the boar and man]. Tejani, A. M., Wasdell, M., Spiwak, R., Rowell, G., and Nathwani, S. Carnitine for fatigue in multiple sclerosis. Broad, E. M., Maughan, R. J., and Galloway S DR. Acta Neurol.Scand. View abstract. View abstract. Cetinkaya, A., Bulbuloglu, E., Kantarceken, B., Ciralik, H., Kurutas, E. B., Buyukbese, M. A., and Gumusalan, Y. View abstract. Yokoi, K., Ito, T., Maeda, Y., Nakajima, Y., Ueta, A., Nomura, T., Koyama, N., Kato, I., Suzuki, S., Kurono, Y., Sugiyama, N., and Togari, H. Acylcarnitine profiles during carnitine loading and fasting tests in a Japanese patient with medium-chain acyl-CoA dehydrogenase deficiency. Metabolism 2008;57(4):549-554. 2003;23(5):270-277. Other research reveals that acetyl-L-carnitine may also help boost brain health and function as you age (64, 65). Neri S, Pistone G, Saraceno B, et al. View abstract. Milio, G., Novo, G., Genova, C., Luigi, Almasio P., Novo, S., and Pinto, A. Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. L-carnitine, ginseng, guarana, glucose, taurine, and more. View abstract. All rights reserved. View abstract. Kumar, A., Singh, R. B., Saxena, M., Niaz, M. A., Josh, S. R., Chattopadhyay, P., Mechirova, V., Pella, D., and Fedacko, J. 10-21-2011;17(39):4414-4420. Propionyl-L-carnitine is likely to be safe when used under medical supervision. View abstract. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. View abstract. Eur J Appl Physiol Occup.Physiol 1987;56(4):457-460. View abstract. 2020;39(5):457-468. 244 Jackson Street. The brain, inflammation and you Inflammation intimately affects sleep quality, especially in older adults. View abstract. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. Huidekoper, H. H., Schneider, J., Westphal, T., Vaz, F. M., Duran, M., and Wijburg, F. A. View abstract. 1995;146(12):769-774. Yet, there are a few known side effects that include agitation, insomnia and nausea. Med.Clin (Barc.) Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. 2009;47(9):748-753. Biogerontology. Do not mix citicoline with levodopa, a medication used to treat Parkinson's disease, without talking to your doctor. Physiologie. Biolo, G., Stulle, M., Bianco, F., Mengozzi, G., Barazzoni, R., Vasile, A., Panzetta, G., and Guarnieri, G. Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. Long-term l-carnitine treatment of chronic anaemia of patients with end-stage renal failure. J Nutr 2007;137(3 Suppl 2):847S-849S. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. 2014 Oct;84(4):821-5. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. Curr Med Res Opin 1990;11:638-47. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. View abstract. View abstract. Acta Paediatr 1996;85:446-9. View abstract. Bernard, A., Rigault, C., Mazue, F., Le, Borgne F., and Demarquoy, J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. It also caused me to urinate a lot. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Muscle carnitine deficiency associated with zidovudine-induced mitochondrial myopathy. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. View abstract. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. Kahn J, Lagakos S, Wulfsohn M, et al. 2007;25(2):182-188. A., and Greenhaff, P. L. Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans. Endocr.J 2010;57(9):777-786. Cell Death.Dis 2010;1:e62. Plasma carnitine deficiency: Clinical observations in 51 pediatric patients. Palazzuoli, V., Mondillo, S., Faglia, S., D'Aprile, N., Camporeale, A., and Gennari, C. [The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy]. View abstract. Be sure to have your blood checked regularly. Rossignol, D. A. and Frye, R. E. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. L-acetylcarnitine (L-AC) (Branigen) in the long term symptomatic treatment of senile dementia. Singh RB, Niaz MA, Agarwal P, et al. Eur.Neuropsychopharmacol. 2013 May;19(5):576-85. Miguel-Carrasco, J. L., Mate, A., Monserrat, M. T., Arias, J. L., Aramburu, O., and Vazquez, C. M. The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension. Cardiovasc.Drugs Ther 2009;23(4):301-306. Thal LJ, Carta A, Clarke WR, et al. View abstract. Wadman, R. I., Bosboom, W. M., van der Pol, W. L., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. Jpn J Clin Pharmacol Ther 1989;20(3):607-618. Park, H. D., Kim, S. R., Ki, C. S., Lee, S. Y., Chang, Y. S., Jin, D. K., and Park, W. S. Two novel HADHB gene mutations in a Korean patient with mitochondrial trifunctional protein deficiency. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Rossini, D., Bulckaen, M., Di, Marco S., Giovannetti, R., Giuntoli, F., Lacopetti, L., and Vergoni, W. [Rehabilitation program in patients with moderate-to-severe intermittent claudication: immediate results and one year follow-up]. Malaguarnera, M., Vacante, M., Giordano, M., Motta, M., Bertino, G., Pennisi, M., Neri, S., Malaguarnera, M., Li, Volti G., and Galvano, F. L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-alpha 2b plus ribavirin.

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